| 5. Round | 04/09/2021 | Lyon-La Duchère | - | AS Monaco B | 0:2 | ||||
| 6. Round | 11/09/2021 | SC Toulon | - | AS Monaco B | 3:0 | ||||
| 8. Round | 25/09/2021 | GFA Rumilly Vallières | - | AS Monaco B | 1:2 |  |
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| 9. Round | 09/10/2021 | AS Monaco B | - | AS Saint-Priest | 4:2 | ||||
| 10. Round | 23/10/2021 | Étoile FC | - | AS Monaco B | 1:1 | ||||
| 11. Round | 06/11/2021 | AS Monaco B | - | GOAL FC | 0:2 | ||||
| 14. Round | 11/12/2021 | Olympique Marseille B | - | AS Monaco B | 0:1 | ||||
| 18. Round | 12/02/2022 | Hyères FC | - | AS Monaco B | 3:1 | ||||
| 19. Round | 19/02/2022 | AS Monaco B | - | Lyon-La Duchère | 2:2 | ||||
| 20. Round | 05/03/2022 | AS Monaco B | - | SC Toulon | 0:1 | |
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| 25. Round | 16/04/2022 | GOAL FC | - | AS Monaco B | 5:0 |
France