| 2. Round | 12/09/2021 | Sevilla FC [Women] | - | Levante UD [Women] | 0:0 | ||||
| 3. Round | 25/09/2021 | Real Sociedad [Women] | - | Sevilla FC [Women] | 2:0 | ||||
| 12. Round | 04/12/2021 | Real Betis [Women] | - | Sevilla FC [Women] | 0:0 | ||||
| 13. Round | 12/12/2021 | Sevilla FC [Women] | - | Atlético Madrid [Women] | 0:0 | ||||
| 16. Round | 08/01/2022 | Madrid CFF [Women] | - | Sevilla FC [Women] | 1:2 | ||||
| 17. Round | 12/01/2022 | Sevilla FC [Women] | - | Rayo Vallecano [Women] | 2:1 | ||||
| 18. Round | 16/01/2022 | Sevilla FC [Women] | - | Valencia CF [Women] | 3:1 |  |
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| 20. Round | 02/02/2022 | Sevilla FC [Women] | - | Villarreal CF [Women] | 0:3 | ||||
| 21. Round | 06/02/2022 | CD Alavés [Women] | - | Sevilla FC [Women] | 1:1 | ||||
| 23. Round | 06/03/2022 | Sevilla FC [Women] | - | Real Betis [Women] | 0:0 | ||||
| 25. Round | 26/03/2022 | Sevilla FC [Women] | - | SD Eibar [Women] | 4:1 | ||||
| 30. Round | 15/05/2022 | Athletic Club [Women] | - | Sevilla FC [Women] | 1:4 | |
Spain