| 1. Round | 06/11/2021 | Olympiakos Piraeus II | - | PAOK Saloniki II | 3:1 | ||||
| 3. Round | 20/11/2021 | Olympiakos Piraeus II | - | AE Lárissa | 1:0 | ||||
| 2. Round | 08/12/2021 | AO Trikala | - | Olympiakos Piraeus II | 0:0 | ||||
| 7. Round | 12/12/2021 | AEP Iraklis FC | - | Olympiakos Piraeus II | 0:0 | ||||
| 13. Round | 12/01/2022 | Thesprotos | - | Olympiakos Piraeus II | 2:1 | ||||
| 14. Round | 15/01/2022 | Olympiakos Piraeus II | - | AO Kavala | 2:2 | ||||
| 11. Round | 19/01/2022 | Pierikos Katerini | - | Olympiakos Piraeus II | 1:2 |  |
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| 15. Round | 22/01/2022 | Almopos Arideas | - | Olympiakos Piraeus II | 3:0 | ||||
| 12. Round | 02/02/2022 | Olympiakos Piraeus II | - | Xanthi FC | 1:1 | ||||
| 17. Round | 05/02/2022 | Olympiakos Volou | - | Olympiakos Piraeus II | 2:3 | ||||
| 32. Round | 16/04/2022 | Olympiakos Piraeus II | - | Almopos Arideas | 2:1 | ||||
| 33. Round | 27/04/2022 | Niki Volou FC | - | Olympiakos Piraeus II | 0:1 | ||||
| 34. Round | 01/05/2022 | Olympiakos Piraeus II | - | Olympiakos Volou | 3:2 |
Greece