 |
 |
|
|
| 15/01/2022 | 12:45 | Olympiakos Piraeus II | - | AO Kavala | 2:2 (2:0) | |
| 16/01/2022 | 12:45 | Apollon Lárissa | - | Almopos Arideas | 1:1 (1:1) | |
| 12:45 | Panserraikos | - | Thesprotos | 2:2 (2:0) | ||
| 12:45 | Veria FC | - | Pierikos Katerini | 4:1 (3:0) | ||
| 15:00 | AE Lárissa | - | Niki Volou FC | 1:0 (1:0) | ||
| 09/02/2022 | 13:00 | AO Trikala | - | Olympiakos Volou | 1:2 (1:1) | |
| 03/03/2022 | 13:00 | AEP Iraklis FC | - | Xanthi FC | 1:0 (1:0) | |
| 16/03/2022 | 13:00 | Apollon Pontou | - | Anagennisi Karditsa | 1:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 13 | 8 | 3 | 2 | 30:13 | 17 | 27 |
| 2 |
|
Anagennisi Karditsa | 14 | 8 | 3 | 3 | 25:12 | 13 | 27 |
| 3 |
|
AE Lárissa | 13 | 7 | 5 | 1 | 18:4 | 14 | 26 |
| 4 |
|
Xanthi FC | 13 | 7 | 4 | 2 | 20:7 | 13 | 25 |
| 5 |
|
Niki Volou FC | 13 | 5 | 5 | 3 | 19:8 | 11 | 20 |
| 6 |
|
Olympiakos Piraeus II | 13 | 4 | 7 | 2 | 15:12 | 3 | 19 |
| 7 |
|
Thesprotos | 13 | 5 | 3 | 5 | 18:11 | 7 | 18 |
| 8 |
|
AEP Iraklis FC | 13 | 3 | 9 | 1 | 9:8 | 1 | 18 |
| 9 |
|
AO Trikala | 14 | 4 | 4 | 6 | 13:21 | -8 | 16 |
| 10 |
|
Almopos Arideas | 13 | 4 | 3 | 6 | 15:14 | 1 | 15 |
| 11 |
|
PAOK Saloniki II | 13 | 3 | 6 | 4 | 15:16 | -1 | 15 |
| 12 |
|
Olympiakos Volou | 13 | 4 | 3 | 6 | 17:20 | -3 | 15 |
| 13 |
|
Apollon Pontou | 13 | 3 | 4 | 6 | 18:22 | -4 | 13 |
| 14 |
|
Pierikos Katerini | 14 | 2 | 6 | 6 | 15:18 | -3 | 12 |
| 15 |
|
Panserraikos | 13 | 2 | 6 | 5 | 13:19 | -6 | 12 |
| 16 |
|
Apollon Lárissa | 13 | 1 | 6 | 6 | 9:19 | -10 | 9 |
| 17 |
|
AO Kavala | 13 | 2 | 3 | 8 | 7:52 | -45 | 9 |
| Playoffs | |
| Relegation |
