| 1. Round | 29/08/2021 | Zamora CF | - | Athletic Club B | 0:1 | ||||
| 2. Round | 05/09/2021 | Athletic Club B | - | Racing Ferrol | 2:2 | ||||
| 4. Round | 17/09/2021 | Athletic Club B | - | Unionistas CF | 0:1 | ||||
| 5. Round | 26/09/2021 | Athletic Club B | - | UD Logroñés | 3:1 | ||||
| 6. Round | 03/10/2021 | CD Tudelano | - | Athletic Club B | 2:2 | ||||
| 7. Round | 08/10/2021 | Athletic Club B | - | RC Celta B | 0:1 | ||||
| 8. Round | 17/10/2021 | Real Valladolid B | - | Athletic Club B | 3:1 | ||||
| 9. Round | 23/10/2021 | Athletic Club B | - | Real Unión | 0:0 | ||||
| 10. Round | 31/10/2021 | SD Logroñés | - | Athletic Club B | 1:1 | ||||
| 11. Round | 07/11/2021 | Athletic Club B | - | Rayo Majadahonda | 1:1 | ||||
| 12. Round | 12/11/2021 | Racing Santander | - | Athletic Club B | 2:0 | ||||
| 14. Round | 28/11/2021 | Deportivo La Coruña | - | Athletic Club B | 1:1 | ||||
| 16. Round | 12/12/2021 | Inter de Madrid | - | Athletic Club B | 3:0 | ||||
| 17. Round | 19/12/2021 | Athletic Club B | - | UD SS Reyes | 0:2 | ||||
| 21. Round | 29/01/2022 | RC Celta B | - | Athletic Club B | 4:1 |  |
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| 35. Round | 08/05/2022 | Athletic Club B | - | CD Calahorra | 1:3 | ||||
| 38. Round | 27/05/2022 | UD SS Reyes | - | Athletic Club B | 2:0 |
Spain