| 2. Round | 12/09/2021 | Burgos Promesas | - | Peña Sport FC | 2:1 | ||||
| 17. Round | 08/01/2022 | AD San Juan | - | Peña Sport FC | 2:1 | ||||
| 18. Round | 23/01/2022 | Arenas de Getxo | - | Peña Sport FC | 6:0 | ||||
| 25. Round | 13/03/2022 | Sestao River | - | Peña Sport FC | 1:0 | ||||
| 26. Round | 20/03/2022 | Peña Sport FC | - | CA Osasuna B | 3:3 | ||||
| 30. Round | 14/04/2022 | Peña Sport FC | - | CD Izarra | 0:1 | ||||
| 31. Round | 24/04/2022 | CD Tropezón | - | Peña Sport FC | 6:1 | ||||
| 32. Round | 30/04/2022 | Peña Sport FC | - | CD Laredo | 1:6 | ||||
| 33. Round | 08/05/2022 | Real Sociedad C | - | Peña Sport FC | 6:1 |
Spain