| 5. Round | 21/09/2024 | Lille OSC | - | RC Strasbourg | 3:3 | ||||
| 6. Round | 28/09/2024 | Havre AC | - | Lille OSC | 0:3 | ||||
| 7. Round | 05/10/2024 | Lille OSC | - | Toulouse FC | 2:1 |  |
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| 8. Round | 18/10/2024 | AS Monaco | - | Lille OSC | 0:0 | ||||
| 9. Round | 26/10/2024 | RC Lens | - | Lille OSC | 0:2 | ||||
| 14. Round | 06/12/2024 | Lille OSC | - | Stade Brestois 29 | 3:1 | ||||
| 15. Round | 14/12/2024 | Olympique Marseille | - | Lille OSC | 1:1 | |
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| 16. Round | 04/01/2025 | Lille OSC | - | FC Nantes | 1:1 | ||||
| 17. Round | 10/01/2025 | AJ Auxerre | - | Lille OSC | 0:0 | |
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| 18. Round | 17/01/2025 | Lille OSC | - | OGC Nice | 2:1 | ||||
| 20. Round | 01/02/2025 | Lille OSC | - | AS Saint-Étienne | 4:1 | ||||
| 21. Round | 08/02/2025 | Lille OSC | - | Havre AC | 1:2 | ||||
| 22. Round | 16/02/2025 | Stade Rennais | - | Lille OSC | 0:2 | ||||
| 25. Round | 08/03/2025 | Lille OSC | - | Montpellier HSC | 1:0 | ||||
| 26. Round | 15/03/2025 | FC Nantes | - | Lille OSC | 1:0 | ||||
| 27. Round | 30/03/2025 | Lille OSC | - | RC Lens | 1:0 | ||||
| 28. Round | 05/04/2025 | Olympique Lyonnais | - | Lille OSC | 2:1 | ||||
| 29. Round | 12/04/2025 | Toulouse FC | - | Lille OSC | 1:2 | ||||
| 30. Round | 20/04/2025 | Lille OSC | - | AJ Auxerre | 3:1 | ||||
| 31. Round | 27/04/2025 | Angers SCO | - | Lille OSC | 0:2 |
Portugal
