| 1. Round | 08/01/2021 | Club Necaxa [Women] | - | Cruz Azul [Women] | 0:2 | ||||
| 2. Round | 19/01/2021 | CF Monterrey [Women] | - | Club Necaxa [Women] | 5:0 | ||||
| 3. Round | 26/01/2021 | Club León [Women] | - | Club Necaxa [Women] | 2:1 | ||||
| 4. Round | 29/01/2021 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 1:1 |  |
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| 5. Round | 04/02/2021 | Club Necaxa [Women] | - | CF América [Women] | 0:1 | ||||
| 6. Round | 09/02/2021 | UANL Tigres [Women] | - | Club Necaxa [Women] | 2:0 | |
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| 7. Round | 12/02/2021 | Club Necaxa [Women] | - | Deportivo Guadalajara [Women] | 0:2 | ||||
| 8. Round | 02/03/2021 | Santos Laguna [Women] | - | Club Necaxa [Women] | 2:2 | ||||
| 9. Round | 05/03/2021 | Club Necaxa [Women] | - | Puebla FC [Women] | 3:2 | ||||
| 10. Round | 12/03/2021 | Mazatlán FC [Women] | - | Club Necaxa [Women] | 2:0 | ||||
| 13. Round | 26/03/2021 | Club Necaxa [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 14. Round | 02/04/2021 | Club Necaxa [Women] | - | FC Juárez [Women] | 2:0 | ||||
| 17. Round | 04/05/2021 | Club Tijuana [Women] | - | Club Necaxa [Women] | 3:0 |
Mexico