 |
 |
|
|
| 02/04/2021 | 00:00 | Atlético San Luis | - | Atlas Guadalajara | 1:2 (1:2) | |
| 23:00 | Club Necaxa | - | FC Juárez | 2:0 (1:0) | ||
| 03/04/2021 | 00:00 | Gallos Blancos | - | Club León | 1:0 (1:0) | |
| 17:00 | Deportivo Guadalajara | - | Pumas UNAM | 4:1 (0:0) | ||
| 04/04/2021 | 18:00 | Puebla FC | - | CF Monterrey | 2:3 (0:3) | |
| 05/04/2021 | 22:00 | Deportivo Toluca | - | Mazatlán FC | 1:0 (0:0) | |
| 06/04/2021 | 01:00 | Santos Laguna | - | CF América | 1:2 (0:0) | |
| 01:00 | UANL Tigres | - | Cruz Azul | 3:0 (1:0) | ||
| 03:00 | CF Pachuca | - | Club Tijuana | 2:1 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 14 | 10 | 3 | 1 | 32:7 | 25 | 33 |
| 2 |
|
Deportivo Guadalajara | 14 | 9 | 3 | 2 | 35:15 | 20 | 30 |
| 3 |
|
Atlas Guadalajara | 14 | 9 | 3 | 2 | 25:18 | 7 | 30 |
| 4 |
|
CF Monterrey | 14 | 9 | 2 | 3 | 36:15 | 21 | 29 |
| 5 |
|
Pumas UNAM | 14 | 7 | 4 | 3 | 19:14 | 5 | 25 |
| 6 |
|
CF Pachuca | 14 | 7 | 3 | 4 | 18:13 | 5 | 24 |
| 7 |
|
Deportivo Toluca | 14 | 6 | 5 | 3 | 14:12 | 2 | 23 |
| 8 |
|
Cruz Azul | 14 | 6 | 4 | 4 | 18:18 | 0 | 22 |
| 9 |
|
CF América | 14 | 5 | 5 | 4 | 20:19 | 1 | 20 |
| 10 |
|
Mazatlán FC | 14 | 4 | 5 | 5 | 12:18 | -6 | 17 |
| 11 |
|
Club Tijuana | 14 | 4 | 3 | 7 | 13:17 | -4 | 15 |
| 12 |
|
Santos Laguna | 14 | 3 | 5 | 6 | 18:24 | -6 | 14 |
| 13 |
|
Gallos Blancos | 14 | 4 | 1 | 9 | 12:21 | -9 | 13 |
| 14 |
|
Club Necaxa | 14 | 3 | 4 | 7 | 12:23 | -11 | 13 |
| 15 |
|
Atlético San Luis | 14 | 2 | 5 | 7 | 15:27 | -12 | 11 |
| 16 |
|
Club León | 14 | 3 | 2 | 9 | 11:28 | -17 | 11 |
| 17 |
|
FC Juárez | 14 | 2 | 3 | 9 | 12:22 | -10 | 9 |
| 18 |
|
Puebla FC | 14 | 1 | 4 | 9 | 10:21 | -11 | 7 |
| Playoffs |
