| 1. Round | 26/07/2021 | Cruz Azul [U18] | - | Mazatlán FC [U18] | 1:1 | ||||
| 2. Round | 01/08/2021 | Santos Laguna [U18] | - | Cruz Azul [U18] | 1:2 | ||||
| 4. Round | 14/08/2021 | Cruz Azul [U18] | - | Deportivo Toluca [U18] | 0:0 | ||||
| 5. Round | 18/08/2021 | Cruz Azul [U18] | - | CF Monterrey [U18] | 1:1 | ||||
| 6. Round | 21/08/2021 | Atlético San Luis [U18] | - | Cruz Azul [U18] | 2:3 |  |
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| 8. Round | 10/09/2021 | FC Juárez [U18] | - | Cruz Azul [U18] | 5:0 | |
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| 10. Round | 24/09/2021 | Puebla FC [U18] | - | Cruz Azul [U18] | 2:1 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U18] | - | Cruz Azul [U18] | 3:2 | ||||
| 13. Round | 16/10/2021 | Cruz Azul [U18] | - | UANL Tigres [U18] | 0:1 | |
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| 14. Round | 19/10/2021 | Atlas Guadalajara [U18] | - | Cruz Azul [U18] | 5:2 | ||||
| 15. Round | 23/10/2021 | Deportivo Guadalajara [U18] | - | Cruz Azul [U18] | 2:1 | ||||
| 16. Round | 31/10/2021 | Cruz Azul [U18] | - | CF América [U18] | 0:0 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U18] | - | Club León [U18] | 2:3 | ||||
| 17. Round | 07/11/2021 | Pumas UNAM [U18] | - | Cruz Azul [U18] | 2:2 |
Mexico