| 1. Round | 06/08/2022 | VfL Bochum | - | 1. FSV Mainz 05 | 1:2 | ||||
| 2. Round | 14/08/2022 | 1. FSV Mainz 05 | - | 1. FC Union Berlin | 0:0 | ||||
| 3. Round | 20/08/2022 | FC Augsburg | - | 1. FSV Mainz 05 | 1:2 | ||||
| 4. Round | 27/08/2022 | 1. FSV Mainz 05 | - | Bayer Leverkusen | 0:3 | ||||
| 5. Round | 04/09/2022 | Bor. Mönchengladbach | - | 1. FSV Mainz 05 | 0:1 | ||||
| 6. Round | 10/09/2022 | 1899 Hoffenheim | - | 1. FSV Mainz 05 | 4:1 | ||||
| 7. Round | 16/09/2022 | 1. FSV Mainz 05 | - | Hertha BSC | 1:1 | ||||
| 8. Round | 01/10/2022 | SC Freiburg | - | 1. FSV Mainz 05 | 2:1 | ||||
| 9. Round | 08/10/2022 | 1. FSV Mainz 05 | - | RB Leipzig | 1:1 | ||||
| 10. Round | 15/10/2022 | Werder Bremen | - | 1. FSV Mainz 05 | 0:2 | ||||
| 11. Round | 21/10/2022 | 1. FSV Mainz 05 | - | 1. FC Köln | 5:0 | ||||
| 12. Round | 29/10/2022 | Bayern München | - | 1. FSV Mainz 05 | 6:2 | ||||
| 13. Round | 05/11/2022 | 1. FSV Mainz 05 | - | VfL Wolfsburg | 0:3 | ||||
| 14. Round | 09/11/2022 | FC Schalke 04 | - | 1. FSV Mainz 05 | 1:0 | ||||
| 16. Round | 21/01/2023 | VfB Stuttgart | - | 1. FSV Mainz 05 | 1:1 |  |
|||
| 17. Round | 25/01/2023 | 1. FSV Mainz 05 | - | Borussia Dortmund | 1:2 |
Ivory Coast