| 7. Round | 26/09/2021 | FC Barcelona | - | Levante UD | 3:0 |  |
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| 8. Round | 02/10/2021 | Atlético Madrid | - | FC Barcelona | 2:0 | ||||
| 9. Round | 17/10/2021 | FC Barcelona | - | Valencia CF | 3:1 | |
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| 10. Round | 24/10/2021 | FC Barcelona | - | Real Madrid | 1:2 | ||||
| 13. Round | 06/11/2021 | RC Celta | - | FC Barcelona | 3:3 | |
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| 34. Round | 01/05/2022 | FC Barcelona | - | RCD Mallorca | 2:1 | ||||
| 35. Round | 07/05/2022 | Real Betis | - | FC Barcelona | 1:2 | |
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| 36. Round | 10/05/2022 | FC Barcelona | - | RC Celta | 3:1 | ||||
| 37. Round | 15/05/2022 | Getafe CF | - | FC Barcelona | 0:0 | ||||
| 38. Round | 22/05/2022 | FC Barcelona | - | Villarreal CF | 0:2 |
Guinea-Bissau
