| 3. Round | 13/09/2020 | Nîmes Olympique | - | Stade Rennais | 2:4 | ||||
| 4. Round | 18/09/2020 | Olympique Lyonnais | - | Nîmes Olympique | 0:0 | ||||
| 5. Round | 27/09/2020 | Nîmes Olympique | - | RC Lens | 1:1 | ||||
| 6. Round | 04/10/2020 | Montpellier HSC | - | Nîmes Olympique | 0:1 |  |
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| 8. Round | 25/10/2020 | Girondins Bordeaux | - | Nîmes Olympique | 2:0 | |
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| 9. Round | 01/11/2020 | Nîmes Olympique | - | FC Metz | 0:1 | ||||
| 10. Round | 08/11/2020 | Nîmes Olympique | - | Angers SCO | 1:5 | ||||
| 18. Round | 06/01/2021 | RC Strasbourg | - | Nîmes Olympique | 5:0 | ||||
| 19. Round | 09/01/2021 | Nîmes Olympique | - | Lille OSC | 0:1 | ||||
| 20. Round | 16/01/2021 | Olympique Marseille | - | Nîmes Olympique | 1:2 | |
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| 22. Round | 31/01/2021 | Angers SCO | - | Nîmes Olympique | 3:1 | ||||
| 23. Round | 03/02/2021 | Paris Saint-Germain | - | Nîmes Olympique | 3:0 | ||||
| 24. Round | 07/02/2021 | Nîmes Olympique | - | AS Monaco | 3:4 | ||||
| 25. Round | 14/02/2021 | Dijon FCO | - | Nîmes Olympique | 0:2 | ||||
| 26. Round | 21/02/2021 | Nîmes Olympique | - | Girondins Bordeaux | 2:0 | ||||
| 31. Round | 04/04/2021 | Nîmes Olympique | - | AS Saint-Étienne | 0:2 | |
France