| 1. Round | 07/08/2021 | Trélissac FC | - | Moulins Yzeure Foot | 0:2 | ||||
| 2. Round | 14/08/2021 | Bergerac Périgord FC | - | Moulins Yzeure Foot | 0:1 |  |
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| 3. Round | 21/08/2021 | Moulins Yzeure Foot | - | AS Béziers | 0:0 | ||||
| 4. Round | 28/08/2021 | Stade Montois | - | Moulins Yzeure Foot | 1:2 | |
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| 5. Round | 04/09/2021 | Moulins Yzeure Foot | - | Bourges Foot 18 | 0:0 | ||||
| 6. Round | 11/09/2021 | Le Puy Foot 43 | - | Moulins Yzeure Foot | 0:0 | ||||
| 7. Round | 18/09/2021 | Moulins Yzeure Foot | - | Angers SCO B | 0:0 | ||||
| 8. Round | 25/09/2021 | Vendée Les Herbiers | - | Moulins Yzeure Foot | 0:2 | ||||
| 9. Round | 09/10/2021 | Moulins Yzeure Foot | - | Montpellier HSC B | 1:2 | ||||
| 10. Round | 23/10/2021 | FC Chamalières | - | Moulins Yzeure Foot | 3:0 | ||||
| 11. Round | 06/11/2021 | Moulins Yzeure Foot | - | Andrézieux-Bouthéon FC | 2:1 | ||||
| 12. Round | 20/11/2021 | US Colomiers | - | Moulins Yzeure Foot | 0:1 | ||||
| 13. Round | 04/12/2021 | Moulins Yzeure Foot | - | FC Nantes B | 1:1 | ||||
| 14. Round | 11/12/2021 | Canet Roussillon | - | Moulins Yzeure Foot | 1:2 |  |
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| 15. Round | 15/01/2022 | Moulins Yzeure Foot | - | Angoulême CFC | 1:1 | ||||
| 16. Round | 22/01/2022 | Moulins Yzeure Foot | - | Bergerac Périgord FC | 0:0 |
France