| 12. Round | 20/11/2021 | Stade Plabennec | - | FC Rouen 1899 | 1:3 |  |
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| 15. Round | 14/01/2022 | FC Rouen 1899 | - | FC Lorient B | 1:1 | ||||
| 16. Round | 22/01/2022 | FC Rouen 1899 | - | AS Poissy | 1:1 | ||||
| 18. Round | 12/02/2022 | Châteaubriant Voltigeurs | - | FC Rouen 1899 | 0:1 | ||||
| 19. Round | 18/02/2022 | FC Rouen 1899 | - | Vannes OC | 0:2 | ||||
| 17. Round | 26/02/2022 | FC Rouen 1899 | - | C'Chartres Football | 0:1 | ||||
| 20. Round | 05/03/2022 | US Granvillaise | - | FC Rouen 1899 | 0:0 | ||||
| 21. Round | 12/03/2022 | FC Rouen 1899 | - | SO Romorantin | 2:1 |  |
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| 22. Round | 19/03/2022 | FC Rouen 1899 | - | SM Caen B | 1:0 | ||||
| 23. Round | 26/03/2022 | AS Vitré | - | FC Rouen 1899 | 2:2 | ||||
| 24. Round | 08/04/2022 | FC Rouen 1899 | - | FC Versailles | 1:1 | ||||
| 25. Round | 16/04/2022 | US Saint-Malo | - | FC Rouen 1899 | 1:4 | ||||
| 26. Round | 23/04/2022 | FC Rouen 1899 | - | Stade Plabennec | 3:0 | |
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| 27. Round | 30/04/2022 | St-Pryvé St-Hilaire | - | FC Rouen 1899 | 1:2 | ||||
| 28. Round | 13/05/2022 | FC Rouen 1899 | - | Blois Foot 41 | 1:0 | ||||
| 29. Round | 21/05/2022 | FC Lorient B | - | FC Rouen 1899 | 1:1 | |
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| 30. Round | 28/05/2022 | FC Rouen 1899 | - | EA Guingamp B | 2:1 | |
France