| 19. Round | 22/01/2022 | Athletic Club B | - | Extremadura UD | 3:0 | ||||
| 20. Round | 25/01/2022 | Athletic Club B | - | Cultural Leonesa | 1:2 | ||||
| 21. Round | 29/01/2022 | RC Celta B | - | Athletic Club B | 4:1 | ||||
| 22. Round | 06/02/2022 | UD Logroñés | - | Athletic Club B | 1:0 | ||||
| 23. Round | 12/02/2022 | Athletic Club B | - | Zamora CF | 1:0 | ||||
| 24. Round | 20/02/2022 | Rayo Majadahonda | - | Athletic Club B | 1:1 | ||||
| 25. Round | 25/02/2022 | Athletic Club B | - | Real Valladolid B | 3:0 | ||||
| 27. Round | 13/03/2022 | Athletic Club B | - | Inter de Madrid | 1:0 | ||||
| 28. Round | 20/03/2022 | CF Talavera | - | Athletic Club B | 4:0 | ||||
| 29. Round | 27/03/2022 | Athletic Club B | - | CD Tudelano | 1:0 | ||||
| 31. Round | 10/04/2022 | Athletic Club B | - | Deportivo La Coruña | 1:1 | ||||
| 32. Round | 16/04/2022 | Real Unión | - | Athletic Club B | 1:1 | ||||
| 33. Round | 24/04/2022 | Athletic Club B | - | SD Logroñés | 1:0 | ||||
| 34. Round | 30/04/2022 | CD Badajoz | - | Athletic Club B | 1:0 | ||||
| 35. Round | 08/05/2022 | Athletic Club B | - | CD Calahorra | 1:3 | ||||
| 37. Round | 21/05/2022 | Athletic Club B | - | Racing Santander | 2:1 | ||||
| 38. Round | 27/05/2022 | UD SS Reyes | - | Athletic Club B | 2:0 |
Spain