| 6. Round | 22/09/2021 | Villarreal CF | - | Elche CF | 4:1 | ||||
| 11. Round | 26/10/2021 | Villarreal CF | - | Cádiz CF | 3:3 | ||||
| 25. Round | 19/02/2022 | Granada CF | - | Villarreal CF | 1:4 |  |
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| 29. Round | 20/03/2022 | Cádiz CF | - | Villarreal CF | 1:0 | ||||
| 31. Round | 09/04/2022 | Villarreal CF | - | Athletic Club | 1:1 | ||||
| 34. Round | 30/04/2022 | CD Alavés | - | Villarreal CF | 2:1 |
Spain