| 1. Round | 07/08/2021 | FC Lorient B | - | AS Vitré | 1:0 | ||||
| 3. Round | 21/08/2021 | FC Lorient B | - | US Saint-Malo | 2:0 |  |
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| 4. Round | 28/08/2021 | Stade Plabennec | - | FC Lorient B | 1:1 |  |
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| 5. Round | 04/09/2021 | FC Lorient B | - | St-Pryvé St-Hilaire | 2:1 | ||||
| 8. Round | 25/09/2021 | FC Lorient B | - | EA Guingamp B | 3:0 | ||||
| 11. Round | 06/11/2021 | Châteaubriant Voltigeurs | - | FC Lorient B | 2:0 | ||||
| 12. Round | 20/11/2021 | FC Lorient B | - | Vannes OC | 1:0 | ||||
| 17. Round | 05/02/2022 | US Saint-Malo | - | FC Lorient B | 2:0 | ||||
| 18. Round | 12/02/2022 | FC Lorient B | - | Stade Plabennec | 1:0 | ||||
| 19. Round | 19/02/2022 | St-Pryvé St-Hilaire | - | FC Lorient B | 1:0 | ||||
| 20. Round | 05/03/2022 | FC Lorient B | - | Blois Foot 41 | 0:1 | ||||
| 21. Round | 12/03/2022 | SM Caen B | - | FC Lorient B | 1:3 | ||||
| 22. Round | 19/03/2022 | EA Guingamp B | - | FC Lorient B | 1:2 | ||||
| 26. Round | 23/04/2022 | Vannes OC | - | FC Lorient B | 0:3 |
France