| 4. Round | 12/09/2021 | Montpellier HSC [Youth] | - | OGC Nice [Youth] | 2:1 | ||||
| 10. Round | 24/10/2021 | Montpellier HSC [Youth] | - | AC Ajaccio [Youth] | 2:2 | ||||
| 11. Round | 14/11/2021 | Nîmes Olympique [Youth] | - | Montpellier HSC [Youth] | 1:3 | ||||
| 12. Round | 21/11/2021 | AS Saint-Étienne [Youth] | - | Montpellier HSC [Youth] | 0:0 | ||||
| 14. Round | 05/12/2021 | Olympique Marseille [Youth] | - | Montpellier HSC [Youth] | 1:2 |  |
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| 16. Round | 22/01/2022 | OGC Nice [Youth] | - | Montpellier HSC [Youth] | 1:2 | ||||
| 17. Round | 06/02/2022 | Montpellier HSC [Youth] | - | Toulouse FC [Youth] | 2:1 | ||||
| 19. Round | 06/03/2022 | Montpellier HSC [Youth] | - | Pieve di Lota [Youth] | 9:0 | |
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| 22. Round | 03/04/2022 | AC Ajaccio [Youth] | - | Montpellier HSC [Youth] | 4:1 | |
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| 25. Round | 01/05/2022 | AS Béziers [Youth] | - | Montpellier HSC [Youth] | 0:1 |
France