| 1. Round | 29/08/2021 | Balma SC [Youth B] | - | Montpellier HSC [Youth B] | 1:5 |  |
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| 2. Round | 04/09/2021 | Montpellier HSC [Youth B] | - | Toulouse FC [Youth B] | 3:1 | |
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| 7. Round | 09/10/2021 | AS Muret [Youth B] | - | Montpellier HSC [Youth B] | 1:4 | |
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| 8. Round | 16/10/2021 | Montpellier HSC [Youth B] | - | AC Vedène [Youth B] | 1:1 | ||||
| 12. Round | 28/11/2021 | Girondins Bordeaux [Youth B] | - | Montpellier HSC [Youth B] | 2:2 | |
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| 14. Round | 15/01/2022 | Toulouse FC [Youth B] | - | Montpellier HSC [Youth B] | 1:0 | ||||
| 23. Round | 10/04/2022 | Rodez AF [Youth B] | - | Montpellier HSC [Youth B] | 1:3 | |
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| 24. Round | 17/04/2022 | Montpellier HSC [Youth B] | - | Girondins Bordeaux [Youth B] | 0:2 |
France