| 1. Round | 05/06/2022 | Independiente II | - | San Lorenzo II | 0:1 | ||||
| 2. Round | 09/06/2022 | Talleres de Córdoba II | - | Independiente II | 0:4 | ||||
| 3. Round | 15/06/2022 | Independiente II | - | Argentinos Juniors II | 0:3 | ||||
| 4. Round | 19/06/2022 | Estudiantes II | - | Independiente II | 1:1 |  |
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| 5. Round | 26/06/2022 | Independiente II | - | Patronato de Paraná II | 7:1 | ||||
| 6. Round | 01/07/2022 | Platense II | - | Independiente II | 0:1 | ||||
| 7. Round | 07/07/2022 | Independiente II | - | Racing Club II | 1:0 | ||||
| 8. Round | 14/07/2022 | Rosario Central II | - | Independiente II | 5:1 | ||||
| 11. Round | 31/07/2022 | Independiente II | - | Colón de Santa Fe II | 1:1 | |
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| 13. Round | 10/08/2022 | Independiente II | - | Lanús II | 1:2 |
Argentina