| 2. Round | 16/01/2022 | Puebla FC [Women] | - | CF Monterrey [Women] | 0:3 | ||||
| 3. Round | 25/01/2022 | CF América [Women] | - | CF Monterrey [Women] | 0:2 | ||||
| 4. Round | 28/01/2022 | CF Monterrey [Women] | - | Mazatlán FC [Women] | 4:0 |  |
|||
| 5. Round | 01/02/2022 | FC Juárez [Women] | - | CF Monterrey [Women] | 1:3 | |
|||
| 6. Round | 08/02/2022 | CF Monterrey [Women] | - | Pumas UNAM [Women] | 5:2 | ||||
| 7. Round | 11/02/2022 | Deportivo Toluca [Women] | - | CF Monterrey [Women] | 1:3 | ||||
| 11. Round | 18/03/2022 | CF Monterrey [Women] | - | Atlético San Luis [Women] | 1:0 | ||||
| 12. Round | 22/03/2022 | Club Tijuana [Women] | - | CF Monterrey [Women] | 2:0 | ||||
| 13. Round | 27/03/2022 | CF Monterrey [Women] | - | Santos Laguna [Women] | 3:1 |  |
|||
| 14. Round | 04/04/2022 | CF Monterrey [Women] | - | CF Pachuca [Women] | 5:0 | |
|||
| 15. Round | 16/04/2022 | Cruz Azul [Women] | - | CF Monterrey [Women] | 1:3 | |
|||
| 16. Round | 26/04/2022 | CF Monterrey [Women] | - | UANL Tigres [Women] | 0:0 | ||||
| 17. Round | 03/05/2022 | Deportivo Guadalajara [Women] | - | CF Monterrey [Women] | 1:0 |
Mexico