| 5. Round | 19/09/2021 | Olympique Lyonnais [Youth] | - | RC Strasbourg [Youth] | 2:3 | ||||
| 7. Round | 03/10/2021 | FC Sochaux [Youth] | - | RC Strasbourg [Youth] | 1:1 | ||||
| 11. Round | 14/11/2021 | Paris FC [Youth] | - | RC Strasbourg [Youth] | 0:0 | ||||
| 15. Round | 27/02/2022 | RC Strasbourg [Youth] | - | AJ Auxerre [Youth] | 2:2 | ||||
| 23. Round | 10/04/2022 | RC Strasbourg [Youth] | - | Paris FC [Youth] | 0:1 | ||||
| 25. Round | 01/05/2022 | RC Strasbourg [Youth] | - | ASPTT Dijon [Youth] | 1:1 | ||||
| 26. Round | 15/05/2022 | FC Bourg-Péronnas [Youth] | - | RC Strasbourg [Youth] | 2:5 |  |
France