| 24. Round | 06/03/2022 | Peña Sport FC | - | Rayo Cantabria | 0:2 | ||||
| 25. Round | 13/03/2022 | Rayo Cantabria | - | CD Cayón | 2:1 | ||||
| 26. Round | 20/03/2022 | Rayo Cantabria | - | Náxara CD | 0:0 | ||||
| 27. Round | 27/03/2022 | Sestao River | - | Rayo Cantabria | 0:0 | ||||
| 28. Round | 02/04/2022 | Rayo Cantabria | - | CA Osasuna B | 0:3 | ||||
| 29. Round | 10/04/2022 | SD Gernika | - | Rayo Cantabria | 1:1 | ||||
| 33. Round | 08/05/2022 | CD Tropezón | - | Rayo Cantabria | 0:2 |  |
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| 34. Round | 15/05/2022 | Rayo Cantabria | - | CD Laredo | 4:1 |
Morocco