| 1. Round | 28/08/2021 | SO Cholet [Youth B] | - | USSA Vertou [Youth B] | 2:0 | ||||
| 2. Round | 04/09/2021 | USSA Vertou [Youth B] | - | CPBB Rennes [Youth B] | 1:1 |  |
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| 3. Round | 11/09/2021 | FC Lorient [Youth B] | - | USSA Vertou [Youth B] | 1:2 | ||||
| 8. Round | 17/10/2021 | USSA Vertou [Youth B] | - | FC Nantes [Youth B] | 0:1 | ||||
| 9. Round | 23/10/2021 | Chamois Niortais [Youth B] | - | USSA Vertou [Youth B] | 3:3 | ||||
| 10. Round | 14/11/2021 | Angers SCO [Youth B] | - | USSA Vertou [Youth B] | 3:2 | ||||
| 11. Round | 21/11/2021 | EA Guingamp [Youth B] | - | USSA Vertou [Youth B] | 2:0 | ||||
| 12. Round | 28/11/2021 | USSA Vertou [Youth B] | - | LB Châteauroux [Youth B] | 2:2 | ||||
| 13. Round | 05/12/2021 | USSA Vertou [Youth B] | - | La Roche VF [Youth B] | 7:0 | ||||
| 16. Round | 06/02/2022 | Angoulême CFC [Youth B] | - | USSA Vertou [Youth B] | 0:1 | ||||
| 17. Round | 12/02/2022 | USSA Vertou [Youth B] | - | Stade Rennais [Youth B] | 1:3 | ||||
| 15. Round | 26/02/2022 | USSA Vertou [Youth B] | - | FC Lorient [Youth B] | 1:0 | ||||
| 18. Round | 05/03/2022 | Vannes OC [Youth B] | - | USSA Vertou [Youth B] | 4:1 | ||||
| 19. Round | 12/03/2022 | USSA Vertou [Youth B] | - | Stade brestois 29 [Youth B] | 1:1 |
France