| 2. Round | 12/09/2021 | Real Madrid [Women] | - | Atlético Madrid [Women] | 0:2 |  |
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| 3. Round | 26/09/2021 | Sporting de Huelva [Women] | - | Atlético Madrid [Women] | 0:3 | ||||
| 6. Round | 09/10/2021 | Atlético Madrid [Women] | - | FC Barcelona [Women] | 0:3 | ||||
| 8. Round | 31/10/2021 | Atlético Madrid [Women] | - | Villarreal CF [Women] | 3:0 | ||||
| 11. Round | 21/11/2021 | SD Eibar [Women] | - | Atlético Madrid [Women] | 0:3 | ||||
| 12. Round | 05/12/2021 | Atlético Madrid [Women] | - | Levante UD [Women] | 2:1 | ||||
| 14. Round | 18/12/2021 | Atlético Madrid [Women] | - | Real Betis [Women] | 6:1 | ||||
| 20. Round | 02/02/2022 | Atlético Madrid [Women] | - | Madrid CFF [Women] | 3:2 | ||||
| 21. Round | 06/02/2022 | Real Sociedad [Women] | - | Atlético Madrid [Women] | 2:2 | ||||
| 15. Round | 09/02/2022 | Athletic Club [Women] | - | Atlético Madrid [Women] | 2:1 | ||||
| 28. Round | 01/05/2022 | Levante UD [Women] | - | Atlético Madrid [Women] | 0:5 | ||||
| 30. Round | 15/05/2022 | FC Barcelona [Women] | - | Atlético Madrid [Women] | 2:1 |
France