| 1. Round | 24/07/2021 | SM Caen | - | Rodez AF | 4:0 | ||||
| 3. Round | 07/08/2021 | SM Caen | - | FC Sochaux | 1:2 | ||||
| 5. Round | 21/08/2021 | SM Caen | - | AS Nancy Lorraine | 1:0 | ||||
| 4. Round | 25/08/2021 | AC Ajaccio | - | SM Caen | 2:0 | ||||
| 6. Round | 28/08/2021 | Nîmes Olympique | - | SM Caen | 0:0 | ||||
| 7. Round | 11/09/2021 | SM Caen | - | Pau FC | 1:2 | ||||
| 14. Round | 30/10/2021 | SM Caen | - | Grenoble Foot 38 | 0:1 | ||||
| 23. Round | 05/02/2022 | AS Nancy Lorraine | - | SM Caen | 1:1 | ||||
| 27. Round | 05/03/2022 | Dijon FCO | - | SM Caen | 1:0 | ||||
| 28. Round | 12/03/2022 | SM Caen | - | Toulouse FC | 4:1 | ||||
| 29. Round | 15/03/2022 | Valenciennes FC | - | SM Caen | 1:1 | ||||
| 30. Round | 19/03/2022 | Havre AC | - | SM Caen | 2:4 |  |
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| 32. Round | 09/04/2022 | Grenoble Foot 38 | - | SM Caen | 0:2 | |
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| 33. Round | 16/04/2022 | SM Caen | - | Amiens SC | 1:1 | ||||
| 34. Round | 19/04/2022 | Paris FC | - | SM Caen | 1:0 | ||||
| 35. Round | 23/04/2022 | SM Caen | - | AJ Auxerre | 1:1 | ||||
| 36. Round | 30/04/2022 | EA Guingamp | - | SM Caen | 2:1 | ||||
| 37. Round | 07/05/2022 | SM Caen | - | US Quevilly-Rouen | 2:0 | |
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| 38. Round | 14/05/2022 | Rodez AF | - | SM Caen | 2:0 |
France