2. Round | 25/07/2021 | River Plate | - | Unión de Santa Fe | 4:0 | ||||
3. Round | 29/07/2021 | Lanús | - | River Plate | 0:3 | ||||
4. Round | 01/08/2021 | River Plate | - | Huracán | 1:1 | ||||
5. Round | 08/08/2021 | Godoy Cruz | - | River Plate | 2:1 | ||||
6. Round | 14/08/2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
9. Round | 30/08/2021 | Sarmiento de Junín | - | River Plate | 1:2 | ||||
10. Round | 06/09/2021 | River Plate | - | Independiente | 1:1 | ||||
11. Round | 16/09/2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
12. Round | 20/09/2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
13. Round | 26/09/2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
14. Round | 03/10/2021 | River Plate | - | Boca Juniors | 2:1 | ||||
15. Round | 09/10/2021 | Banfield | - | River Plate | 0:1 | ||||
16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | ||||
17. Round | 22/10/2021 | Talleres de Córdoba | - | River Plate | 0:2 | ||||
18. Round | 25/10/2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
19. Round | 31/10/2021 | Estudiantes | - | River Plate | 1:1 | ||||
20. Round | 07/11/2021 | River Plate | - | Patronato de Paraná | 5:0 | ||||
25. Round | 11/12/2021 | Atlético Tucumán | - | River Plate | 1:1 |