| 3. Round | 25/01/2022 | Deportivo Guadalajara [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 4. Round | 28/01/2022 | Club Necaxa [Women] | - | Deportivo Guadalajara [Women] | 0:3 | ||||
| 7. Round | 13/02/2022 | Deportivo Guadalajara [Women] | - | Santos Laguna [Women] | 1:0 | ||||
| 8. Round | 27/02/2022 | Atlético San Luis [Women] | - | Deportivo Guadalajara [Women] | 0:0 | ||||
| 10. Round | 14/03/2022 | CF América [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 11. Round | 18/03/2022 | Deportivo Guadalajara [Women] | - | Club Tijuana [Women] | 3:0 | ||||
| 12. Round | 22/03/2022 | Deportivo Guadalajara [Women] | - | Puebla FC [Women] | 1:0 | ||||
| 14. Round | 04/04/2022 | Mazatlán FC [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 9. Round | 11/04/2022 | Deportivo Guadalajara [Women] | - | FC Juárez [Women] | 0:0 | ||||
| 16. Round | 23/04/2022 | Atlas Guadalajara [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 17. Round | 03/05/2022 | Deportivo Guadalajara [Women] | - | CF Monterrey [Women] | 1:0 |
Mexico