| 3. Round | 26/09/2021 | Levante UD [Women] | - | Real Betis [Women] | 1:1 | ||||
| 4. Round | 29/09/2021 | Real Betis [Women] | - | UDG Tenerife Sur [Women] | 2:2 | ||||
| 5. Round | 03/10/2021 | Sporting de Huelva [Women] | - | Real Betis [Women] | 0:1 | ||||
| 6. Round | 10/10/2021 | Real Betis [Women] | - | Madrid CFF [Women] | 4:5 | ||||
| 9. Round | 06/11/2021 | Real Sociedad [Women] | - | Real Betis [Women] | 4:0 | ||||
| 10. Round | 13/11/2021 | Real Betis [Women] | - | Real Madrid [Women] | 1:4 | ||||
| 11. Round | 21/11/2021 | Valencia CF [Women] | - | Real Betis [Women] | 1:0 | ||||
| 13. Round | 12/12/2021 | Rayo Vallecano [Women] | - | Real Betis [Women] | 0:2 | ||||
| 14. Round | 18/12/2021 | Atlético Madrid [Women] | - | Real Betis [Women] | 6:1 | ||||
| 15. Round | 22/12/2021 | Real Betis [Women] | - | Villarreal CF [Women] | 0:1 | ||||
| 16. Round | 09/01/2022 | Real Betis [Women] | - | Levante UD [Women] | 1:0 | ||||
| 17. Round | 12/01/2022 | Athletic Club [Women] | - | Real Betis [Women] | 1:1 | ||||
| 18. Round | 16/01/2022 | Real Betis [Women] | - | SD Eibar [Women] | 2:0 | ||||
| 21. Round | 06/02/2022 | Real Madrid [Women] | - | Real Betis [Women] | 1:0 |
USA