| 1. Round | 06/02/2022 | Nacional | - | Deportivo Maldonado | 2:3 | ||||
| 2. Round | 12/02/2022 | Rentistas | - | Nacional | 0:4 |  |
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| 3. Round | 21/02/2022 | Nacional | - | Liverpool | 0:0 | ||||
| 5. Round | 13/03/2022 | Nacional | - | Montevideo City Torque | 1:1 | ||||
| 8. Round | 10/04/2022 | Boston River | - | Nacional | 0:6 | ||||
| 9. Round | 17/04/2022 | Nacional | - | River Plate | 1:1 | |
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| 10. Round | 23/04/2022 | Cerro Largo | - | Nacional | 0:2 |
Uruguay