| 1. Round | 16/07/2021 | Unión de Santa Fe II | - | Boca Juniors II | 1:0 | ||||
| 2. Round | 23/07/2021 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 3. Round | 27/07/2021 | Unión de Santa Fe II | - | Banfield II | 0:1 | ||||
| 4. Round | 30/07/2021 | Lanús II | - | Unión de Santa Fe II | 2:1 | ||||
| 6. Round | 13/08/2021 | Huracán II | - | Unión de Santa Fe II | 0:1 | ||||
| 8. Round | 26/08/2021 | Godoy Cruz II | - | Unión de Santa Fe II | 3:0 |
Argentina