| 1. Round | 25/06/2022 | Club Necaxa [] | - | Gallos Blancos [] | 3:0 | ||||
| 2. Round | 02/07/2022 | Deportivo Toluca [] | - | Club Necaxa [] | 2:0 | ||||
| 5. Round | 23/07/2022 | CF Pachuca [] | - | Club Necaxa [] | 1:2 | ||||
| 6. Round | 30/07/2022 | Club Necaxa [] | - | FC Juárez [] | 8:0 |  |
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| 7. Round | 06/08/2022 | CF América [] | - | Club Necaxa [] | 1:0 | ||||
| 8. Round | 13/08/2022 | Club Necaxa [] | - | Puebla FC [] | 1:0 | ||||
| 11. Round | 03/09/2022 | Club Necaxa [] | - | Deportivo Toluca [] | 2:0 | |
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| 10. Round | 13/09/2022 | Gallos Blancos [] | - | Club Necaxa [] | 0:0 | ||||
| 13. Round | 17/09/2022 | Pumas UNAM [] | - | Club Necaxa [] | 2:1 | ||||
| 14. Round | 24/09/2022 | Club Necaxa [] | - | CF Pachuca [] | 0:0 | ||||
| 9. Round | 28/09/2022 | Cruz Azul [] | - | Club Necaxa [] | 0:2 | |
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| 15. Round | 01/10/2022 | FC Juárez [] | - | Club Necaxa [] | 2:2 |  |
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| 16. Round | 09/10/2022 | Club Necaxa [] | - | CF América [] | 5:2 | ||||
| 17. Round | 15/10/2022 | Puebla FC [] | - | Club Necaxa [] | 1:5 | ||||
| 18. Round | 22/10/2022 | Club Necaxa [] | - | Cruz Azul [] | 3:0 |
Mexico