| 1. Round | 22/01/2022 | Deportivo Pasto | - | Millonarios | 0:1 | ||||
| 2. Round | 26/01/2022 | Atlético Bucaramanga | - | Millonarios | 0:0 | ||||
| 4. Round | 02/02/2022 | Envigado FC | - | Millonarios | 0:0 | ||||
| 8. Round | 19/02/2022 | Jaguares de Córdoba | - | Millonarios | 1:2 |  |
|||
| 9. Round | 27/02/2022 | Millonarios | - | Cortuluá | 1:0 | ||||
| 14. Round | 03/04/2022 | América de Cali | - | Millonarios | 3:2 | ||||
| 15. Round | 09/04/2022 | Millonarios | - | La Equidad | 2:1 | ||||
| 17. Round | 25/04/2022 | Millonarios | - | Santa Fe | 2:1 | ||||
| 18. Round | 01/05/2022 | Patriotas FC | - | Millonarios | 1:2 |  |
|
||
| 19. Round | 09/05/2022 | Millonarios | - | Deportes Tolima | 0:0 | ||||
| 20. Round | 15/05/2022 | Millonarios | - | Alianza Petrolera | 1:0 |
Colombia