| Group 1 | 27/02/2018 | Defensor Sporting | - | Grêmio Porto Alegre | 1:1 | ||||
| Group 1 | 14/03/2018 | Cerro Porteño | - | Defensor Sporting | 2:1 |  |
|||
| Group 1 | 17/04/2018 | Defensor Sporting | - | Monagas | 3:1 | |
 |
||
| Group 1 | 26/04/2018 | Monagas | - | Defensor Sporting | 1:0 | ||||
| Group 1 | 15/05/2018 | Defensor Sporting | - | Cerro Porteño | 0:1 | |
|||
| Group 1 | 23/05/2018 | Grêmio Porto Alegre | - | Defensor Sporting | 1:0 | |
Uruguay
Italy 