| 1. Round | 03/09/2022 | FC Cartagena B | - | Real Betis B | 0:1 |  |
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| 3. Round | 18/09/2022 | FC Cartagena B | - | Cádiz CF B | 1:1 | ||||
| 4. Round | 25/09/2022 | Antequera CF | - | FC Cartagena B | 2:0 | ||||
| 5. Round | 02/10/2022 | FC Cartagena B | - | CD El Ejido 2012 | 1:0 | ||||
| 6. Round | 09/10/2022 | Recreativo Granada | - | FC Cartagena B | 1:2 | ||||
| 7. Round | 16/10/2022 | Utrera CD | - | FC Cartagena B | 3:2 | ||||
| 11. Round | 20/11/2022 | Xerez DFC | - | FC Cartagena B | 0:2 | ||||
| 12. Round | 27/11/2022 | FC Cartagena B | - | Vélez CF | 2:1 | ||||
| 13. Round | 04/12/2022 | Juventud Torremolinos | - | FC Cartagena B | 1:2 | ||||
| 15. Round | 18/12/2022 | UCAM Murcia CF | - | FC Cartagena B | 6:1 | ||||
| 27. Round | 26/03/2023 | Sevilla Atlético | - | FC Cartagena B | 1:1 | ||||
| 28. Round | 02/04/2023 | FC Cartagena B | - | Xerez DFC | 0:1 | ||||
| 30. Round | 16/04/2023 | FC Cartagena B | - | Juventud Torremolinos | 2:3 | ||||
| 31. Round | 23/04/2023 | Atlético Mancha Real | - | FC Cartagena B | 1:3 | |
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| 32. Round | 30/04/2023 | FC Cartagena B | - | UCAM Murcia CF | 1:0 | ||||
| 33. Round | 07/05/2023 | Yeclano Deportivo | - | FC Cartagena B | 0:0 | ||||
| 34. Round | 14/05/2023 | FC Cartagena B | - | CD San Roque de Lepe | 1:1 |
Spain