| 1. Round | 25/07/2021 | Pumas UNAM [U18] | - | Atlas Guadalajara [U18] | 1:2 | ||||
| 2. Round | 31/07/2021 | Atlas Guadalajara [U18] | - | FC Juárez [U18] | 2:1 | ||||
| 3. Round | 09/08/2021 | CF Pachuca [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 6. Round | 21/08/2021 | Atlas Guadalajara [U18] | - | Deportivo Toluca [U18] | 2:0 | ||||
| 7. Round | 28/08/2021 | UANL Tigres [U18] | - | Atlas Guadalajara [U18] | 0:0 | ||||
| 8. Round | 11/09/2021 | Atlas Guadalajara [U18] | - | CF Monterrey [U18] | 4:0 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U18] | - | Atlas Guadalajara [U18] | 1:0 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U18] | - | Club León [U18] | 2:3 | ||||
| 12. Round | 02/10/2021 | Deportivo Guadalajara [U18] | - | Atlas Guadalajara [U18] | 3:0 | ||||
| 13. Round | 15/10/2021 | Mazatlán FC [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 14. Round | 19/10/2021 | Atlas Guadalajara [U18] | - | Cruz Azul [U18] | 5:2 | ||||
| 15. Round | 24/10/2021 | Atlético San Luis [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 16. Round | 28/10/2021 | Atlas Guadalajara [U18] | - | Club Tijuana [U18] | 1:0 | ||||
| 17. Round | 04/11/2021 | Atlas Guadalajara [U18] | - | Gallos Blancos [U18] | 2:1 |  |
Mexico