| 2. Round | 14/08/2021 | Le Puy Foot 43 | - | FC Nantes B | 1:1 | ||||
| 6. Round | 11/09/2021 | FC Chamalières | - | FC Nantes B | 2:2 | ||||
| 8. Round | 25/09/2021 | US Colomiers | - | FC Nantes B | 0:2 | ||||
| 3. Round | 02/10/2021 | FC Nantes B | - | Angers SCO B | 1:1 | ||||
| 9. Round | 09/10/2021 | FC Nantes B | - | Bergerac Périgord FC | 0:0 | ||||
| 10. Round | 23/10/2021 | FC Nantes B | - | Canet Roussillon | 1:2 | ||||
| 11. Round | 05/11/2021 | Angoulême CFC | - | FC Nantes B | 1:1 | ||||
| 12. Round | 20/11/2021 | FC Nantes B | - | Trélissac FC | 2:1 | ||||
| 13. Round | 04/12/2021 | Moulins Yzeure Foot | - | FC Nantes B | 1:1 |
France