| 4. Round | 28/08/2021 | FC Martigues | - | Louhans-Cuiseaux | 1:1 | ||||
| 5. Round | 04/09/2021 | Louhans-Cuiseaux | - | GFA Rumilly Vallières | 2:0 |  |
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| 6. Round | 11/09/2021 | AS Saint-Priest | - | Louhans-Cuiseaux | 0:2 | ||||
| 7. Round | 17/09/2021 | Louhans-Cuiseaux | - | Étoile FC | 0:0 | ||||
| 8. Round | 25/09/2021 | GOAL FC | - | Louhans-Cuiseaux | 2:0 | ||||
| 9. Round | 09/10/2021 | Louhans-Cuiseaux | - | Aubagne FC | 3:2 | ||||
| 10. Round | 23/10/2021 | Jura Sud | - | Louhans-Cuiseaux | 1:1 | |
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| 11. Round | 06/11/2021 | Louhans-Cuiseaux | - | Olympique Marseille B | 0:1 |
France
Ghana