| 1. Round | 05/09/2021 | CF La Nucía | - | Mar Menor CF | 1:0 | ||||
| 3. Round | 19/09/2021 | CF La Nucía | - | UD Socuéllamos | 0:0 | ||||
| 5. Round | 03/10/2021 | CF La Nucía | - | Levante UD B | 1:0 | ||||
| 7. Round | 17/10/2021 | CS Puertollano CF | - | CF La Nucía | 1:2 | ||||
| 11. Round | 14/11/2021 | UD Melilla | - | CF La Nucía | 1:0 | ||||
| 15. Round | 12/12/2021 | CD Marchamalo | - | CF La Nucía | 0:3 |  |
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| 16. Round | 19/12/2021 | CF La Nucía | - | Recreativo Granada | 0:0 | ||||
| 17. Round | 09/01/2022 | CF Intercity | - | CF La Nucía | 1:1 |
Spain