| 6. Round | 25/09/2021 | Angers SCO [Youth] | - | EA Guingamp [Youth] | 0:3 | ||||
| 7. Round | 03/10/2021 | Le Mans FC [Youth] | - | Angers SCO [Youth] | 2:1 | ||||
| 8. Round | 10/10/2021 | Angers SCO [Youth] | - | SA Mérignac [Youth] | 2:1 | ||||
| 9. Round | 17/10/2021 | USSA Vertou [Youth] | - | Angers SCO [Youth] | 1:1 | ||||
| 10. Round | 24/10/2021 | Angers SCO [Youth] | - | Girondins Bordeaux [Youth] | 0:0 | ||||
| 1. Round | 31/10/2021 | US Avranches [Youth] | - | Angers SCO [Youth] | 2:2 | ||||
| 11. Round | 14/11/2021 | FC Nantes [Youth] | - | Angers SCO [Youth] | 2:1 | ||||
| 13. Round | 28/11/2021 | Angers SCO [Youth] | - | LB Châteauroux [Youth] | 0:1 | ||||
| 14. Round | 04/12/2021 | US Concarneau [Youth] | - | Angers SCO [Youth] | 2:2 | ||||
| 20. Round | 06/02/2022 | Angers SCO [Youth] | - | Stade Brestois 29 [Youth] | 0:2 | ||||
| 24. Round | 17/04/2022 | Angers SCO [Youth] | - | Tours FC [Youth] | 4:1 | ||||
| 25. Round | 01/05/2022 | LB Châteauroux [Youth] | - | Angers SCO [Youth] | 1:1 |
France