| 1. Round | 05/09/2021 | Real Sociedad [Women] | - | Valencia CF [Women] | 4:1 | ||||
| 2. Round | 12/09/2021 | Athletic Club [Women] | - | Real Sociedad [Women] | 0:1 | ||||
| 3. Round | 25/09/2021 | Real Sociedad [Women] | - | Sevilla FC [Women] | 2:0 | ||||
| 4. Round | 29/09/2021 | Real Madrid [Women] | - | Real Sociedad [Women] | 0:1 | ||||
| 5. Round | 03/10/2021 | Real Sociedad [Women] | - | Villarreal CF [Women] | 4:0 | ||||
| 6. Round | 10/10/2021 | Rayo Vallecano [Women] | - | Real Sociedad [Women] | 1:3 | ||||
| 7. Round | 17/10/2021 | Real Sociedad [Women] | - | Levante UD [Women] | 0:1 | ||||
| 9. Round | 06/11/2021 | Real Sociedad [Women] | - | Real Betis [Women] | 4:0 | ||||
| 11. Round | 21/11/2021 | Real Sociedad [Women] | - | UDG Tenerife Sur [Women] | 3:0 | ||||
| 12. Round | 05/12/2021 | Madrid CFF [Women] | - | Real Sociedad [Women] | 1:2 |  |
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| 15. Round | 22/12/2021 | CD Alavés [Women] | - | Real Sociedad [Women] | 0:4 | |
USA