| 1. Round | 02/07/2022 | Club Necaxa | - | Deportivo Toluca | 1:3 |  |
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| 2. Round | 10/07/2022 | Deportivo Toluca | - | Atlas Guadalajara | 3:2 | ||||
| 3. Round | 14/07/2022 | CF América | - | Deportivo Toluca | 1:0 |  |
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| 6. Round | 30/07/2022 | FC Juárez | - | Deportivo Toluca | 1:1 | ||||
| 16. Round | 03/08/2022 | Deportivo Toluca | - | Puebla FC | 1:1 | |
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| 7. Round | 07/08/2022 | Deportivo Toluca | - | Club Tijuana | 3:1 | |
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| 8. Round | 14/08/2022 | Cruz Azul | - | Deportivo Toluca | 2:3 | ||||
| 9. Round | 18/08/2022 | Deportivo Toluca | - | CF Monterrey | 1:1 | ||||
| 10. Round | 21/08/2022 | Atlético San Luis | - | Deportivo Toluca | 1:0 | ||||
| 11. Round | 28/08/2022 | Deportivo Toluca | - | CF Pachuca | 1:4 | ||||
| 12. Round | 04/09/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 0:0 | ||||
| 13. Round | 08/09/2022 | UANL Tigres | - | Deportivo Toluca | 3:1 | ||||
| 14. Round | 11/09/2022 | Deportivo Toluca | - | Pumas UNAM | 2:2 | ||||
| 15. Round | 17/09/2022 | Mazatlán FC | - | Deportivo Toluca | 1:1 | |
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| 17. Round | 02/10/2022 | Deportivo Toluca | - | Gallos Blancos | 4:1 |
Chile