| 24. Round | 04/02/2018 | Stade Rennais | - | EA Guingamp | 0:1 | ||||
| 25. Round | 10/02/2018 | EA Guingamp | - | SM Caen | 0:0 | ||||
| 26. Round | 17/02/2018 | Montpellier HSC | - | EA Guingamp | 1:1 |  |
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| 27. Round | 24/02/2018 | EA Guingamp | - | FC Metz | 2:2 | ||||
| 28. Round | 03/03/2018 | Angers SCO | - | EA Guingamp | 3:0 | ||||
| 29. Round | 11/03/2018 | EA Guingamp | - | OGC Nice | 2:5 |  |
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| 30. Round | 18/03/2018 | AS Saint-Étienne | - | EA Guingamp | 2:0 | ||||
| 31. Round | 01/04/2018 | EA Guingamp | - | Girondins Bordeaux | 2:1 | |
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| 32. Round | 07/04/2018 | EA Guingamp | - | ESTAC Troyes | 4:0 | ||||
| 33. Round | 14/04/2018 | Lille OSC | - | EA Guingamp | 2:2 | ||||
| 34. Round | 21/04/2018 | EA Guingamp | - | AS Monaco | 3:1 | ||||
| 35. Round | 29/04/2018 | Paris Saint-Germain | - | EA Guingamp | 2:2 | ||||
| 36. Round | 06/05/2018 | Dijon FCO | - | EA Guingamp | 3:1 | ||||
| 37. Round | 11/05/2018 | EA Guingamp | - | Olympique Marseille | 3:3 | |
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| 38. Round | 19/05/2018 | Toulouse FC | - | EA Guingamp | 2:1 | |
France
