| 1. Round | 12/09/2021 | AEK Athen | - | Ionikos Nikea | 3:0 | ||||
| 2. Round | 19/09/2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
| 3. Round | 22/09/2021 | AEK Athen | - | Lamia | 1:0 | ||||
| 4. Round | 26/09/2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
| 5. Round | 03/10/2021 | Panetolikos | - | AEK Athen | 1:3 | ||||
| 8. Round | 31/10/2021 | AEK Athen | - | Aris Saloniki | 2:1 | ||||
| 9. Round | 06/11/2021 | Apollon Smyrnis | - | AEK Athen | 2:2 | ||||
| 10. Round | 21/11/2021 | AEK Athen | - | Olympiakos Piraeus | 2:3 | ||||
| 11. Round | 27/11/2021 | PAS Giannina | - | AEK Athen | 1:2 | ||||
| 12. Round | 05/12/2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 13. Round | 11/12/2021 | Asteras Tripolis | - | AEK Athen | 0:0 | ||||
| 14. Round | 16/12/2021 | Ionikos Nikea | - | AEK Athen | 0:1 | ||||
| 15. Round | 20/12/2021 | AEK Athen | - | OFI Heraklion | 1:2 | ||||
| 19. Round | 23/01/2022 | Atromitos | - | AEK Athen | 0:2 | ||||
| 20. Round | 30/01/2022 | AEK Athen | - | Volos NFC | 1:2 | ||||
| 22. Round | 06/02/2022 | AEK Athen | - | Apollon Smyrnis | 3:0 | ||||
| 24. Round | 20/02/2022 | AEK Athen | - | PAS Giannina | 2:0 | ||||
| 17. Round | 02/03/2022 | AEK Athen | - | PAOK Saloniki | 1:1 | ||||
| 26. Round | 06/03/2022 | AEK Athen | - | Asteras Tripolis | 2:1 |  |
France