| 1. Round | 08/08/2021 | Stade Rennais | - | RC Lens | 1:1 | ||||
| 2. Round | 15/08/2021 | RC Lens | - | AS Saint-Étienne | 2:2 | ||||
| 4. Round | 29/08/2021 | RC Lens | - | FC Lorient | 2:2 | ||||
| 10. Round | 17/10/2021 | Montpellier HSC | - | RC Lens | 1:0 |  |
|||
| 11. Round | 24/10/2021 | RC Lens | - | FC Metz | 4:1 | ||||
| 12. Round | 30/10/2021 | Olympique Lyonnais | - | RC Lens | 2:1 | ||||
| 14. Round | 21/11/2021 | Stade Brestois 29 | - | RC Lens | 4:0 | ||||
| 15. Round | 26/11/2021 | RC Lens | - | Angers SCO | 2:2 | ||||
| 16. Round | 01/12/2021 | Clermont Foot 63 | - | RC Lens | 2:2 | |
|||
| 18. Round | 10/12/2021 | FC Nantes | - | RC Lens | 3:2 | ||||
| 19. Round | 22/12/2021 | OGC Nice | - | RC Lens | 2:1 | ||||
| 20. Round | 08/01/2022 | RC Lens | - | Stade Rennais | 1:0 | ||||
| 21. Round | 15/01/2022 | AS Saint-Étienne | - | RC Lens | 1:2 | ||||
| 22. Round | 22/01/2022 | RC Lens | - | Olympique Marseille | 0:2 | ||||
| 34. Round | 23/04/2022 | Paris Saint-Germain | - | RC Lens | 1:1 |  |
|||
| 36. Round | 08/05/2022 | Stade de Reims | - | RC Lens | 1:2 | ||||
| 38. Round | 21/05/2022 | RC Lens | - | AS Monaco | 2:2 |
France