| 3. Round | 22/02/2022 | Unión de Santa Fe | - | Atlético Tucumán | 1:0 | ||||
| 4. Round | 02/03/2022 | Atlético Tucumán | - | Patronato de Paraná | 1:0 | ||||
| 5. Round | 06/03/2022 | Newell's Old Boys | - | Atlético Tucumán | 4:0 | ||||
| 6. Round | 14/03/2022 | Atlético Tucumán | - | Racing Club | 0:4 | ||||
| 7. Round | 22/03/2022 | Atlético Tucumán | - | Central Córdoba SdE | 0:1 | ||||
| 8. Round | 03/04/2022 | San Lorenzo | - | Atlético Tucumán | 1:1 | ||||
| 9. Round | 08/04/2022 | Atlético Tucumán | - | Gimnasia de La Plata | 1:2 | ||||
| 10. Round | 17/04/2022 | Defensa y Justicia | - | Atlético Tucumán | 1:1 | ||||
| 11. Round | 21/04/2022 | Atlético Tucumán | - | Argentinos Juniors | 2:4 | ||||
| 12. Round | 24/04/2022 | River Plate | - | Atlético Tucumán | 1:1 | ||||
| 13. Round | 30/04/2022 | Atlético Tucumán | - | Talleres de Córdoba | 3:0 |  |
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| 14. Round | 10/05/2022 | Banfield | - | Atlético Tucumán | 1:1 |
Argentina