| 1. Round | 06/08/2022 | Fortuna Sittard | - | AFC Ajax | 2:3 | ||||
| 2. Round | 14/08/2022 | AFC Ajax | - | FC Groningen | 6:1 | ||||
| 3. Round | 21/08/2022 | Sparta Rotterdam | - | AFC Ajax | 0:1 | ||||
| 4. Round | 28/08/2022 | FC Utrecht | - | AFC Ajax | 0:2 | ||||
| 5. Round | 03/09/2022 | AFC Ajax | - | SC Cambuur | 4:0 | ||||
| 6. Round | 10/09/2022 | AFC Ajax | - | sc Heerenveen | 5:0 | ||||
| 7. Round | 18/09/2022 | AZ Alkmaar | - | AFC Ajax | 2:1 | ||||
| 8. Round | 01/10/2022 | AFC Ajax | - | Go Ahead Eagles | 1:1 | ||||
| 9. Round | 08/10/2022 | FC Volendam | - | AFC Ajax | 2:4 | ||||
| 10. Round | 16/10/2022 | AFC Ajax | - | SBV Excelsior | 7:1 | ||||
| 11. Round | 22/10/2022 | RKC Waalwijk | - | AFC Ajax | 1:4 |  |
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| 12. Round | 09/11/2022 | AFC Ajax | - | Vitesse | 2:2 | ||||
| 14. Round | 12/11/2022 | FC Emmen | - | AFC Ajax | 3:3 |
Netherlands
England 
