1. Round | 08/01/2022 | Pumas UNAM [Women] | - | Club León [Women] | 1:0 | ||||
3. Round | 25/01/2022 | CF Pachuca [Women] | - | Club León [Women] | 3:0 | ||||
4. Round | 28/01/2022 | Club León [Women] | - | Club Tijuana [Women] | 1:1 | ||||
5. Round | 01/02/2022 | Club León [Women] | - | Gallos Blancos [Women] | 4:2 | ||||
6. Round | 08/02/2022 | Santos Laguna [Women] | - | Club León [Women] | 1:3 | ||||
7. Round | 11/02/2022 | Club León [Women] | - | CF América [Women] | 1:4 | ||||
11. Round | 17/03/2022 | Club León [Women] | - | Puebla FC [Women] | 2:0 | ||||
12. Round | 22/03/2022 | UANL Tigres [Women] | - | Club León [Women] | 6:0 | ||||
13. Round | 29/03/2022 | Club León [Women] | - | Deportivo Guadalajara [Women] | 0:2 | ||||
14. Round | 01/04/2022 | Club León [Women] | - | Cruz Azul [Women] | 2:3 | ||||
9. Round | 11/04/2022 | Club León [Women] | - | CF Monterrey [Women] | 1:6 | ||||
15. Round | 15/04/2022 | Atlético San Luis [Women] | - | Club León [Women] | 4:0 | ||||
16. Round | 26/04/2022 | Club León [Women] | - | Deportivo Toluca [Women] | 2:2 | ||||
17. Round | 02/05/2022 | Atlas Guadalajara [Women] | - | Club León [Women] | 2:1 |