| 1. Round | 29/07/2021 | CF Monterrey II | - | Cancún FC | 1:2 |  |
|||
| 2. Round | 08/08/2021 | Atlante | - | CF Monterrey II | 2:1 | ||||
| 7. Round | 08/09/2021 | CF Monterrey II | - | TM Fútbol Club | 0:0 | ||||
| 8. Round | 16/09/2021 | Cimarrones de Sonora | - | CF Monterrey II | 1:2 | ||||
| 9. Round | 21/09/2021 | CF Monterrey II | - | Mineros de Zacatecas | 0:1 | ||||
| 11. Round | 06/10/2021 | CF Monterrey II | - | Coyotes de Tlaxcala | 4:1 | ||||
| 12. Round | 16/10/2021 | Dorados de Sinaloa | - | CF Monterrey II | 4:1 | ||||
| 13. Round | 19/10/2021 | CF Monterrey II | - | Leones Negros | 0:1 | ||||
| 15. Round | 07/11/2021 | CF Monterrey II | - | Pumas Tabasco | 1:1 | ||||
| 17. Round | 16/11/2021 | CF Monterrey II | - | Atlético Morelia | 0:1 |
Mexico